Endocrine Abstracts

Attainment of mammalian reproductive capacity depends on an increased pulsatile release of gonadotropin releasing hormone (GnRH) from hypothalamus neurons. After reaching the pituitary gland GnRH stimulates the synthesis and release of gonadotropins, which in turn promote gonadal function. The pubertal activation of GnRH secretion is brought about by coordinated changes in transsynaptic and glial-neuronal communication, which involve an increase in neuronal and glial excitator...